Renal handling of nitrate in women and men with elevated blood pressure

Aim The inorganic anions nitrate and nitrite are oxidation products of nitric oxide (NO) that have often been used as an index NO generation. More than just being surrogate markers NO, nitrate/nitrite can recycle to bioactive again. Nitrate is predominantly eliminated via the kidneys; however, there less knowledge regarding tubular handling. aim this study, part a large randomized controlled trial, was explore potential sex differences in renal handling during low high dietary intake. We hypothesized clearance excretion higher men compared women. Methods In prehypertensive hypertensive individuals (n = 231), were measured plasma urine at intake (baseline) after 5 weeks supplementation with (300 mg potassium nitrate/day) or placebo chloride/day). Twenty-four hours ambulatory blood pressure recordings collections conducted. Results At baseline, nitrite, well downstream marker signalling cyclic guanosine monophosphate, similar women men. Approximately 80% filtered spared by kidneys. Urinary concentration, amount excreted, (Cnitrate) fractional (FEnitrate) lower No association observed between concentrations glomerular filtration rate (GFR), nor FEnitrate GFR either sex. After increased significantly, but remained unchanged. significantly difference baseline disappeared. Conclusion Our findings demonstrate substantial sparing capacity kidneys, which This suggests reabsorption underlying mechanism(s) warrants further investigation.